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Medically reviewed by L. Last updated on Feb 16, Viagra sildenafil is one of the most widely-known prescription drug names on the U. Often dubbed "the little blue pill", Viagra sildenafil was the first phosphodiesterase 5 PDE5 inhibitor approved to treat erectile dysfunction ED. ED is a common sexual problem for men and its frequency increases with age. It is estimated roughly 30 million men in the U. The discovery that sildenafil could lead to an erection was an unplanned event.

The sildenafil compound was originally developed by Pfizer for the treatment of hypertension high blood pressure and angina pectoris chest pain due to heart disease. During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain. In , the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review.

Pfizer promoted Viagra and ED awareness via direct-to-consumer DTC advertising, which prompted men to seek medical advice and a prescription from their doctors. For many men, the stigma and embarrassment of talking to their doctor about ED has declined since the introduction of Viagra and other PDE5 inhibitors. Erectile dysfunction ED , or the inability to achieve and maintain an erect penis for sexual function, can lead to performance anxiety, a negative impact on self-esteem and personal relationships, and even clinical depression.

In a survey published in BMJ , 62 percent of men reported a decline in self esteem, 29 percent reported a negative effect on a relationship, and 21 percent reported that their relationship had ceased due to ED. For many men, the inability to perform adequately during sex directly affects their feelings of masculinity. Risk factors for ED include underlying health issues such as diabetes, high blood pressure, obesity, high cholesterol, chronic alcohol or drug abuse, certain medications, and injuries, all of which can also contribute to erectile dysfunction ED.

Any condition that may restrict blood flow to veins over time, like smoking and normal aging, can lead to ED. Mental health issues can take their toll, too -- depression or stress can result in loss of libido.

Erection failures may occur repeatedly in men who experience performance anxiety due to ED. Many medications have impotence or sexual dysfunction listed as a side effect. A medication review should be performed by a health care provider to determine if any prescription drug treatment may be contributing to symptoms. If you regularly experience sexual function or ED problems, contact your doctor for evaluation and treatment.

Viagra works in response to sexual stimulation to increase the blood flow to the penis leading to an erection. Viagra does not result in an erection without sexual stimulation.

When a man is aroused, muscles in the penis relax to allow this greater blood flow. Viagra helps to elevate the levels of a substance cyclic guanosine monophosphate, or cGMP that causes the tissues to relax, leads to an inflow of blood, and causes an erection with sexual stimulation.

However, knowing that one can perform better in bed may indirectly boost libido. Several of these agents are now available generically, too, which can help in the wallet.

Viagra sildenafil is taken by mouth usually as a 25 or 50 milligram mg tablet one hour before sexual activity.

However, Viagra may be taken within a range of one-half hour to four hours before sex. The dose may be adjusted based on doctor recommendations, but it should not exceed mg per dose and should not be taken more than once per day. A physician will prescribe your specific dose. Have your pharmacist check for drug interactions , too. Men who use nitrates such as nitroglycerin or isosorbide should never use Viagra or other PDE5 inhibitors Cialis, Levitra, Stenda, or Staxyn due to severe, possibly fatal hypotension low blood pressure.

In general, the most common side effects with PDE5 inhibitors like Viagra are mild and short-lived. Side effects may include:. Report a sudden hearing or vision loss to your healthcare provider immediately. An erection lasting more then 4 hours priapism is a rare event, but if it occurs get emergency treatment.

Be sure to review Viagra drug interactions and precautions with your healthcare provider prior to use. Your dose of Viagra may need to be adjusted based on other drugs you may be taking. The simplicity of taking an oral tablet for erectile dysfunction has revolutionized treatment.

However, PDE5 inhibitors may not work in about 30 percent of men. It is important for men to know that there are other options available for ED. These solutions were used prior to Viagra, and are still available today:. These options may be useful for some; however, for many men they can be complicated, painful, and more expensive. Be sure to talk to your doctor about all options.

Media advertising has dramatically, and sometimes sensationally, increased the awareness of "Low-T" or low blood testosterone also called androgen deficiency. Men with low blood testosterone levels may suffer from a lower sex drive, erectile dysfunction ED , brittle bones osteoporosis , low muscle mass and higher fat accumulation.

However, a report from the Testosterone Trials noted that testosterone therapy can raise the risk of heart disease and stroke, and may not be safe is men with low-but-normal testosterone levels and no outward symptoms related to low T. Testosterone therapy is available by injection, gel, skin patch, spray or lozenge to raise testosterone levels.

However, in addition to heart risks, older men who take testosterone replacements may need to have regular prostate cancer screening tests. Plus, testosterone therapy currently carries a boxed warning of potential heart risks, mandated by the FDA. One more important point: Erectile dysfunction drugs have finally become affordable due to generic availability.

However, some men still prefer the brand names. Much of the advertised Viagra on the Internet is counterfeit , and may even contain dangerous and toxic drugs. To help combat the counterfeit market, Pfizer now offers online Viagra prescription orders and home delivery through licensed pharmacies. Just check out their website at Viagra. In December , generic versions of Viagra became commercially available, which has lowered cost considerably. Know that these prices can vary based on the pharmacy, your location, and if you use an online pharmacy coupon.

Another option is to talk to your doctor about using the generic form of Revatio sildenafil , approved for pulmonary hypertension. Viagra has become the victim of Internet fraud due to its rapid success and famous name. According to Pfizer, 80 percent of the top 22 Internet sites that came up in search results for the phrase "buy Viagra" were selling counterfeit pills.

Products sold as "natural" or "herbal" Viagra claim to enhance performance; however, these illegal products have not undergone FDA review or approval. Fraudulent Viagra products contain unknown chemical ingredients that may pose a serious health risk.

More than 50 million women experience some type of sexual dysfunction. Studies looking at Viagra in women have theorized that sildenafil could increase genital blood flow and boost arousal. However, most studies have found a limited beneficial effect of Viagra for women. Lack of sex drive in a woman is a complicated process, often magnified by stress, hormonal changes, or lack of intimacy. However, medications to help boost libido in women are becoming available.

Addyi flibanserin was approved in August to treat low sex drive -- generalized hypoactive sexual desire disorder HSDD in pre-menopausal women. Osphena ospemifene , as well as Intrarosa prasterone are available for vaginal dryness and dyspareunia painful intercourse that can interfere with sex in menopausal women. In May , Imvexxy estradiol vaginal insert was also approved for females who experience painful sexual intercourse.

Other medications used for the treatment of erectile dysfunction, Cialis generic: For most men interested in cost savings, switching to the generic forms may be a good option if they use other brands such as Staxyn vardenafil , an orally disintegrating form of vardenafil, or Stendra avanafil. Generic options for these brands are not yet on the market.

Ask your doctor or pharmacist about switching. If you prefer not to switch to the generic, be sure to check with the manufacturer of the product you use to determine if they have discount programs that might help save you some money.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records.

Available for Android and iOS devices. Subscribe to receive email notifications whenever new articles are published. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

We comply with the HONcode standard for trustworthy health information - verify here. The Unexpected Discovery of Viagra. Which Medications Cause ED? Medications that may lead to erectile dysfunction include: Just the Basic Facts: Does Viagra Have Side Effects? Side effects may include: Headache Flushing Heartburn Vision problems Nausea Dizziness Report a sudden hearing or vision loss to your healthcare provider immediately.

Other Options for Erectile Dysfunction. These solutions were used prior to Viagra, and are still available today: Penile self-injection Caverject Transurethral suppositories MUSE Vacuum-assisted erection devices Surgical penile prostheses These options may be useful for some; however, for many men they can be complicated, painful, and more expensive. What is Low T? These trials were a set of seven year-long clinical trials conducted at 12 sites across the United States.

Overall, the Testosterone Trials showed that the volume of arterial plaque increased more in the testosterone-treated group compared to the untreated "control" group, which could increase the risk over time for heart attack or stroke. But at What Cost?

Viagra: How a Little Blue Pill Changed the World Форум : Ветеринарная клиника Балашиха ветклиника «АЛЬФА»

Blue cross viagra

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